28th May 2007

Green Tea polyphenols help prevent skin cancer.

Recent research on green tea, a review of the medical literature,  investigated whether (EGCG) epigallocatechin gallate can be beneficial for the health of sun-exposed skin. Scientists searched the medical literature for studies that investigated the photoprotective efficacy of green tea polyphenols against ultraviolet-induced carcinogenesis known as photocarcinogenesis.

The reviewers concluded that oral administration of green tea polyphenols in drinking water or the topical application of epigallocatechin gallate prevents UVB-induced skin tumor development in mice. The researchers also concluded that the mechanism of action behind green tea’s effects includes the ability to initiate DNA repair and the ability to inhibit the suppressed immunity that occurs after excessive exposure to sunlight. In addition, green tea inhibits angiogenesis, the development of new blood vessels that feed cancer cells.

According to the reviewers, “New mechanistic information strongly supports and explains the chemopreventive activity of green tea polyphenols against photocarcinogenesis.”
epigallocatechin gallate can support the health of sun-exposed skin. Scientists searched the medical literature for studies that investigated the photoprotective efficacy of green tea polyphenols against ultraviolet-induced carcinogenesis known as photocarcinogenesis. The reviewers concluded that oral administration of green tea polyphenols in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in mice. The researchers also concluded that the mechanism of action behind green tea’s effects includes the ability to initiate DNA repair and the ability to inhibit the suppressed immunity that occurs after excessive exposure to sunlight. In addition, green tea inhibits angiogenesis, the development of new blood vessels that feed cancer cells.

According to the reviewers, “New mechanistic information strongly supports and explains the chemopreventive activity of green tea polyphenols against photocarcinogenesis.”

Suchitra Kativar, Craig A Elmets, Santosh K Katiyar. Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. The Journal of Nutritional Biochemistry. 2007 May 18 (5):287-296

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29th April 2007

Green Tea Improves Blood Vessel Function

Recent research shows Green tea extract reverses vascular dysfunction in patients with coronary artery disease in humans.
In the first study, researchers sought an explanation for why previous research has shown that the green tea component epigallocatechin gallate (EGCG) can support the health of the heart.

In the double blind, placebo-controlled, crossover design trial, the researchers studied 42 subjects randomly assigned to receive either an epigallocatechin gallate supplement or a placebo. Before the subjects crossed-over to the other intervention, they underwent a one-week washout where they consumed neither the placebo nor the epigallocatechin gallate.

Researchers then measured brachial artery flow-mediated dilation (FMD) in the arm, which is an indicator of how well blood is flowing through vessels. The researchers measured flow-mediated dilation through a vascular ultrasound at baseline, again two hours after subjects received an initial dose of EGCG (300 mg) or placebo, and after two weeks of supplementation with EGCG (two 150 mg doses per day) or a placebo.

Supplementation with the green tea extract improved flow-mediated dilation from 7.1 to 8.6 percent two hours after the initial 300 milligram dose. In addition, blood levels of EGCG correlated with improved vascular function. Placebo treatment had no significant effect.

The study authors concluded, “epigallocatechin gallate acutely improves endothelial function in humans with coronary artery disease, and may account for a portion of the beneficial effects of flavonoid-rich food on endothelial function.”

[seems polyphenols in flavonoid rich foods are implicated yet again in improving cardio-vascular health, still prefer to get mine from red wine & dark chocolate though.]

(a word of caution, this research published by VRP (vitamin research products) who incidentally produce “Green Tea Extract”.)

Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF Jr, Vita JA. Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease. J Am Coll Nutr. 2007 Apr 26 (2):95-102

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